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KMID : 0359319910310040419
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Korean Journal of Veterinary Research
1991 Volume.31 No. 4 p.419 ~ p.424
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Administration of ethylenethiourea during organogenesis periods in pregnant rats .
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Abstract
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This study was carried out to investigate; the alpha-fetoprotein, urea and free fatty acid in amniotic fluids and water filled multiple T-maze test of fetuses affected by Ethylenethiourea. The S.P.F. Sprague-Dawley female rats(10 weeks) were used in this study and these animals were divided into four groups; control group I (l0㎎/㎏/day), group II (30㎎/㎏/day), group III (50㎎/㎏/day).
The results obtained were summarized as follows;
1. In the water filled multiple T-maze test of Fl male rats, The time and errors from start point to goal point of 30㎎/㎏ group are significantly(p<0.001) increased from control group in 3rd day of test. In Fl female rats of 2nd day and 3rd day of water filled multiple T-maze test, The time and some errors in 30㎎/㎏ gronp are significantly (p<0.05) increased from control group.
2. Alpha-fetoprotein values of all treated groups(l0㎎/㎏, 30㎎/㎏ and 50㎎/㎏) were significantly(p<0.001) decreased from control values in the amniotic fluids.
3. Urea values of ammniotic fluids in 50㎎/㎏ group are significantly increased from control group.
4. Free fatty acid values of ammniotic fluids in 50㎎/㎏ group are significantly increased from control group.
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